Heteroz collections are unique small molecule libraries, designed for screening based on chemical genetics, chemical biology, and target validation. We provide custom compound library services based on your unique collection of compounds.
The minimum order size is 80 compounds either as 1mg solid/dry compound or as 100 μL 10 mM DMSO stock. The libraries are available pre-dissolved in DMSO, and include compounds targeting caspases, GPCRs, kinases, ion channels, nuclear receptors, transporters and stem cell biology. We also add a few new molecules with known biological activities. Each compound is provided as a 100 μL, 10mM DMSO solution. Compounds are dispensed into robot friendly 1.4mL alphanumeric Trakmate tubes and sealed with pre-split SepraSeal caps. Our library of small molecules is mainly useful for the study of the following research areas.
Ion channels are proteins located in the plasma membrane. Each of these proteins arranges itself so that it forms a passageway or pore extending from one side of the membrane to the other. These passageways or ion channels have the ability to open and close in response to chemical or mechanical signals. There are different types of ion channels in plasma membrane based on gating mechanism like voltage-gated, ligand-gated or light-gated ion channels. They are also classified by ion selectivity like sodium, proton, potassium, calcium or chloride. The disruption of normal ion channel leads to diseases. We've a stock of a wide range of activators, or blockers and modulators for calcium, potassium, sodium and TRP ion channels. Please contact us for a complete list of products.
Apoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. It is triggrered by a variety of stimuli, including cell surface receptors like FAS, mitochondrial response to stress, and cytotoxic T cells. The two major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondira-associated) pathways, both of which are found in the cytoplasm. We've products both for as apoptosis inducers that could be promising agents for cancer chemotherapy also as apoptosis inhibitors that could promote normal cell survival by inhibiting the activities of caspases. Apoptosis inhibitors will not only reduce the side effects of cancer therapy but also for control of neurodegenerative disorders such as Parkinson's Alzheimers's, and Huntington's diseases.
Protein kinases are enzymes that add a phosphate group to other proteins. There are more than 500 kinases which can be grouped into about 20 known families on the basis of structure relatedness. They have emerged as key regulators of all aspects of neoplasea, including proliferation, invasion, angiogenesis and metastasis. The deregulation of kinase function has been implicated in disorders, including immunological, neurological, metabolic and infectious diseases. Therapeutic small molecules as kinase inhibitors have been highly beneficial to cancer patients and offer the promise of future therapies for the other diseases as well. We've as stock of more than 450 unique small molecules as kinase inhibitors.
Epigenetics involves any potentially stable and, ideally, heritable change in gene expression or chromosome stability that doesn't alter the underlying DNA sequence. These changes are established through multiple mechanism that include DNA methylation, non-coding RNAs and the covalent modification of specific residue on histone proteins. We've a collection of several small molecule modulatores (activators or inhibitors) of HATs, HDACs, and HMTases that can be directly used for your research or we can modify these molecules to enhance their effectiveness.
Stem Cells have the ability to self-renew as well as to differentiate into defined cellular subtypes. There are four categories of stem cells including embryonic, adult, cancer and induced pluripotent stem cells. They possess great promise as therapeutic tools for neurological disorders, cerebrovascular diseases, neutotraumata and demyelinating diseases. Currently we're generating new molecules that could play an integral part in the advancement of stem cell research.
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